Publications
A. Relevant Publications by Dr. Shobha Ghosh:
Improved insulin sensitivity in high-fat high-cholesterol fed LDLR-/- mice with macrophage-specific transgenic expression of cholesteryl ester hydrolase: Role of macrophage inflammation and infiltration into adipose tissue. Bie J, Zhao B, Song J, Ghosh S. J Biol Chem. 2010 Feb 26.
Macrophage cholesteryl ester mobilization and atherosclerosis. Ghosh S, Zhao B, Bie J, Song J.Vascul Pharmacol. 2010 Jan-Feb; 52(1-2):1-10. Epub 2009 Oct 28.
Hepatic overexpression of cholesteryl ester hydrolase enhances cholesterol elimination and in vivo reverse cholesterol transport. Zhao B, Song J, Ghosh S. J Lipid Res. 2008 Oct; 49(10):2212-7. Epub 2008 Jul 3.
Macrophage-specific transgenic expression of cholesteryl ester hydrolase significantly reduces atherosclerosis and lesion necrosis in Ldlr mice. Zhao B, Song J, Chow WN, St Clair RW, Rudel LL, Ghosh S. J Clin Invest. 2007 Oct; 117(10):2983-92.
Stable overexpression of human macrophage cholesteryl ester hydrolase results in enhanced free cholesterol efflux from human THP1 macrophages. Zhao B, Song J, St Clair RW, Ghosh S. Am J Physiol Cell Physiol. 2007 Jan; 292(1):C405-12. Epub 2006 Sep 13.
Human liver cholesteryl ester hydrolase: cloning, molecular characterization, and role in cellular cholesterol homeostasis. Zhao B, Natarajan R, Ghosh S. Physiol Genomics. 2005 Nov 17; 23(3):304-10. Epub 2005 Aug 30.
Redistribution of macrophage cholesteryl ester hydrolase from cytoplasm to lipid droplets upon lipid loading. Zhao B, Fisher BJ, St Clair RW, Rudel LL, Ghosh S. J Lipid Res. 2005 Oct; 46(10):2114-21.
Mobilization of cytoplasmic CE droplets by overexpression of human macrophage cholesteryl ester hydrolase. Ghosh S, St Clair RW, Rudel LL. J Lipid Res. 2003 Oct; 44(10):1833-40. Epub 2003 Jul 1.
B. Relevant Publications by Drs. Robert Kisilevsky and Tom Tam:
Heparan sulfate promotes the aggregation of HDL-associated serum amyloid A: evidence for a proamyloidogenic histidine molecular switch. Elimova E, Kisilevsky R, Ancsin JB. FASEB J. 2009 Oct; 23(10):3436-48. Epub 2009 Jun 23.
Acute-phase-HDL remodeling by heparan sulfate generates a novel lipoprotein with exceptional cholesterol efflux activity from macrophages. Tam SP, Kisilevsky R, Ancsin JB. PLoS One. 2008; 3(12):e3867. Epub 2008 Dec 5.
Serum amyloid A, in vivo splenic cholesterol export and its potential implications in hemolytic disorders. Li C, Kisilevsky R. Amyloid. 2008 Dec; 15(4):246-54.
The anti-atherogenic potential of serum amyloid A peptides. Kisilevsky R, Tam SP, Ancsin JB. Curr Opin Investig Drugs. 2008 Mar; 9(3):265-73. Review.
The path of murine serum amyloid A through peritoneal macrophages. Kinkley SM, Bagshaw WL, Tam SP, Kisilevsky R. Amyloid. 2006 Sep; 13(3):123-34.
Peptides derived from serum amyloid A prevent, and reverse, aortic lipid lesions in apoE-/- mice. Tam SP, Ancsin JB, Tan R, Kisilevsky R. J Lipid Res. 2005 Oct; 46(10):2091-101. Epub 2005 Aug 1.
Macrophage cholesterol efflux and the active domains of serum amyloid A 2.1. Kisilevsky R, Tam SP. J Lipid Res. 2003 Dec; 44(12):2257-69. Epub 2003 Sep 1.
Promoting export of macrophage cholesterol: the physiological role of a major acute-phase protein, serum amyloid A 2.1. Tam SP, Flexman A, Hulme J, Kisilevsky R. J Lipid Res. 2002 Sep; 43(9):1410-20.
Acute phase serum amyloid A, cholesterol metabolism, and cardiovascular disease. Kisilevsky R, Tam SP. Pediatr Pathol Mol Med. 2002 May-Jun; 21(3):291-305. Review.
The in-vitro influence of serum amyloid A isoforms on enzymes that regulate the balance between esterified and un-esterified cholesterol. Ely S, Bonatesta R, Ancsin JB, Kindy M, Kisilevsky R. Amyloid. 2001 Sep; 8(3):169-81.